Clinical characteristics of early-onset AD

 
   Lead Investigator:    Brad Dickerson
   Institution      :    Massachusetts General Hospital
   E-Mail           :    bradd@nmr.mgh.harvard.edu
   Proposal ID      :    179


   Publications:


1  Barnes J, Dickerson B, Frost C, Jiskoot LC, Wolk D, van der Flier WM
   Alzheimer's disease first symptoms are age dependent: Evidence from the NACC dataset
   Journal Article  Alzheimers Dement,11:1349-1357,2015,PMC4619185

   PUBLISHED





   Proposal Description:
   We aim to test the hypothesis that early onset AD carries a distinct clinical phenotype relative to late onset AD, similar to that which we have previously described (Dickerson et al., JNNP 2011), with more prominent executive/attentional impairment and less prominent primary memory impairment.  To accomplish this goal, we would like to evaluate all patients with a clinical diagnosis of PRAD or POAD at any point in their clinical course, and assess  all longitudinal data for each subject in part to be as confident as possible that the subject's diagnosis was consistently AD.